Hsd17b4 Gene Summary [Mouse]
Enables 3-hydroxyacyl-CoA dehydratase activity and 3-hydroxyacyl-CoA dehydrogenase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Located in peroxisome. Is active in peroxisomal matrix. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b4 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 4 [Source:MGI Symbol;Acc:MGI:105089] |
| Ensembl ID | ENSMUSG00000024507 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 4 |
| Synonyms | 17-beta-HSD, 17-beta HSD4, 17 beta Hydroxy Steroid Dehydrogenase Isoform 4, 17[b]-HSD, 17-β-HSD, 17-β HSD4, 17 β Hydroxy Steroid Dehydrogenase Isoform 4, Bifunctional, D-bifunctional, DBP, HD, hydroxysteroid (17-beta) dehydrogenase 4, hydroxysteroid 17-beta dehydrogenase 4, hydroxysteroid (17-β) dehydrogenase 4, hydroxysteroid 17-β dehydrogenase 4, MFE-2, MFP-2, MPF-2, NS1-I, perMFE-2, Peroxisomal bifunctional, Peroxisomal bifunctional enzyme, Ph, Pmeii, PRLTS1, SDR8C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsd17b4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3(or 17)beta-hydroxysteroid dehydrogenase
- 3-hydroxyacyl-CoA dehydrogenase
- estradiol 17beta-dehydrogenase
- 3-hydroxybutyrate dehydrogenase
- SCP-2 sterol transfer family
- KR domain
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- identical protein binding
- enoyl-CoA hydratase
- polyketide synthase keto reductase domain
- MaoC like domain
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoacetyl-CoA reductase
- 3-hydroxyacyl-CoA dehydratase
- CH-OH group:NAD or NADP oxidoreductase
- protein homodimerization
- hot_dog
- short chain dehydrogenase
- steroid dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- multiple sclerosis
- COVID-19
- bifunctional peroxisomal enzyme deficiency
- alcoholism
- Perrault syndrome type 1
- hepatitis B virus-related hepatocellular carcinoma
- growth failure
- endometriosis
role in cell
- abnormal morphology
- development
- degeneration
- hydration in
- upregulation in
- beta-oxidation in
- dehydrogenation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cellular membrane
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsd17b4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very long-chain fatty-acyl-CoA metabolic process
- medium-chain fatty-acyl-CoA metabolic process
- fatty acid beta-oxidation
- androgen metabolic process
- estrogen metabolic process
- osteoblast differentiation
- Sertoli cell development
- very long-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- 3-hydroxyacyl-CoA dehydratase activity
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
- protein homodimerization activity
- 3-hydroxyacyl-CoA dehydrogenase activity
- 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
- enoyl-CoA hydratase activity
- isomerase activity