Rhoc Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in apical junction assembly and positive regulation of protein-containing complex assembly. Located in nucleus; plasma membrane; and stereocilium. Is expressed in hippocampus. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhoc |
| Official Name | ras homolog family member C [Source:MGI Symbol;Acc:MGI:106028] |
| Ensembl ID | ENSMUSG00000002233 |
| Bio databases IDs | |
| Aliases | ras homolog family member C |
| Synonyms | ARH9, ARHC, H9, ras homolog family member C, RAS HOMOLOG GENE family, member C, Rhoc1, Rhoc predicted, RHOH9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhoc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- GTPase domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the Rhoc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pervasive developmental disorder
- metastasis
- tumorigenesis
- diffuse cutaneous systemic sclerosis
- non-small cell lung cancer
- adenoma formation
- non-small cell lung carcinoma
- hypertension
- aldosterone producing adrenocortical adenoma
role in cell
- phosphorylation in
- apoptosis
- growth
- expression in
- proliferation
- activation in
- invasion
- function
- disruption
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microvesicles
- cellular membrane
- Nucleus
- cytosol
- stereocilia
- endoplasmic reticulum membrane
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhoc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- small GTPase mediated signal transduction
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- actin filament organization
- regulation of actin cytoskeleton organization
- positive regulation of stress fiber assembly
- cytokinesis after mitosis
- apical junction assembly
- positive regulation of lipase activity
- positive regulation of protein complex assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular vesicular exosome
- cleavage furrow
- cytosol
- stereocilium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity