Trmt5 Gene Summary [Mouse]
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trmt5 |
| Official Name | TRM5 tRNA methyltransferase 5 [Source:MGI Symbol;Acc:MGI:1923607] |
| Ensembl ID | ENSMUSG00000034442 |
| Bio databases IDs | |
| Aliases | TRM5 tRNA methyltransferase 5 |
| Synonyms | 2610027O18Rik, COXPD26, KIAA1393, mKIAA1393, PNSED, RGD1306567, TRM5, TRM5 tRNA methyltransferase 5, tRNA methyltransferase 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Met-10+ like-protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial tRNA methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- tRNA (guanine(37)-N(1))-methyltransferase activity
- tRNA methyltransferase activity