TRMT5 Gene Summary [Human]
tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRMT5 |
| Official Name | tRNA methyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:23141] |
| Ensembl ID | ENSG00000126814 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase 5, tRNA (guanine(37)-N1)-methyltransferase |
| Synonyms | 2610027O18Rik, COXPD26, KIAA1393, mKIAA1393, PNSED, RGD1306567, TRM5, TRM5 tRNA methyltransferase 5, tRNA methyltransferase 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRMT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Met-10+ like-protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRMT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial tRNA methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- tRNA (guanine(37)-N(1))-methyltransferase activity
- tRNA methyltransferase activity