Uri1 Gene Summary [Mouse]
Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Is expressed in several structures, including alimentary system; brain; epithelium; genitourinary system; and muscle tissue. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uri1 |
| Official Name | URI1, prefoldin-like chaperone [Source:MGI Symbol;Acc:MGI:1342294] |
| Ensembl ID | ENSMUSG00000030421 |
| Bio databases IDs | |
| Aliases | URI1, prefoldin-like chaperone |
| Synonyms | C19orf2, NNX3, PPP1R19, RGD1310358, RMP, URI, URI1 prefoldin like chaperone, URI1, prefoldin-like chaperone |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uri1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- polr2e binding domain
- prefoldin
- transcription co-repressor
- enzyme binding
- phosphoprotein binding
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- ovarian cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- chronic periodontal disease
regulated by
- TCF4
- metribolone
role in cell
- proliferation
- growth
- expression in
- cell cycle progression
- apoptosis
- colony formation by
- transcription in
- recruitment in
- transactivation in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uri1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to steroid hormone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of phosphatase activity
- regulation of cell growth
- cellular response to growth factor stimulus
- response to virus
- protein stabilization
- negative regulation of intrinsic apoptotic signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- transcription corepressor activity
- phosphatase inhibitor activity
- phosphoprotein binding
- chromatin binding
- RNA polymerase II core binding