Polr3e Gene Summary [Mouse]
Predicted to be involved in DNA-templated transcription; defense response to virus; and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3e |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide E [Source:MGI Symbol;Acc:MGI:1349452] |
| Ensembl ID | ENSMUSG00000030880 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide E |
| Synonyms | C37, KIAA1452, polymerase (RNA) III (DNA directed) polypeptide E, RGD1308086, RNA polymerase III subunit E, RPC5, SIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YXXP domain
- DNA-directed RNA polymerase III subunit RPC5 C-terminal
- transcription regulator
- RPC5 protein
- Sh3 domain binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- defense response to virus
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm