Mad2l1bp Gene Summary [Mouse]
Predicted to be involved in deactivation of mitotic spindle assembly checkpoint and regulation of exit from mitosis. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleus. Orthologous to human MAD2L1BP (MAD2L1 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mad2l1bp |
| Official Name | MAD2L1 binding protein [Source:MGI Symbol;Acc:MGI:1913841] |
| Ensembl ID | ENSMUSG00000034509 |
| Bio databases IDs | |
| Aliases | MAD2L1 binding protein |
| Synonyms | 0610009D16Rik, 2510031P20RIK, CMT2, CMT2A, CMT2B, KIAA0110, MAD2L1 binding protein, Mad2lbp, mKIAA0110, P31COMET |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mad2l1bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mad1 and Cdc20-bound-Mad2 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- organismal death
- Waldenström macroglobulinemia
- growth failure
- B cell cancer
role in cell
- proliferation
- apoptosis
- mitosis
- olaparib resistance
- fragmentation
- movement
- aneuploidy
- mitotic index
- destabilization in
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mad2l1bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of exit from mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- spindle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding