Mcc Gene Summary [Mouse]
Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcc |
| Official Name | mutated in colorectal cancers [Source:MGI Symbol;Acc:MGI:96930] |
| Ensembl ID | ENSMUSG00000071856 |
| Bio databases IDs | |
| Aliases | mutated in colorectal cancers |
| Synonyms | A930012L18RIK, D18Ertd451e, E330037C19, LOC100909638, LOC100909795, MCC1, MCC regulator of WNT signaling pathway, mutated in colorectal cancers, RGD1561988 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain
- signaling receptor activity
- EF-hand domain pair
- EFh
- PDZ domain of MCC-2 bdg protein for Usher syndrome
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- hypertension
- metabolic syndrome X
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- androgenic alopecia
role in cell
- expression in
- proliferation
- differentiation
- migration by
- SN-38 sensitivity
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- negative regulation of canonical Wnt receptor signaling pathway
- signal transduction
- negative regulation of epithelial cell proliferation
- negative regulation of epithelial cell migration
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity