Rit1 Gene Summary [Mouse]
Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; liver; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rit1 |
| Official Name | Ras-like without CAAX 1 [Source:MGI Symbol;Acc:MGI:108053] |
| Ensembl ID | ENSMUSG00000028057 |
| Bio databases IDs | |
| Aliases | Ras-like without CAAX 1 |
| Synonyms | NS8, Ras-like without CAAX 1, RGD1559874, RIBB, Ric/Rit, RIT, ROC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- hypertension
- cancer
- colorectal cancer
- Noonan syndrome 8
- Parkinson disease
- schizophrenia
- Noonan syndrome type 1
- lung adenocarcinoma
role in cell
- phosphorylation in
- differentiation
- apoptosis
- proliferation
- binding in
- cell death
- activation in
- colony formation
- mitotic defect
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- calmodulin binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding