Hsd17b13 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b13 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 13 [Source:MGI Symbol;Acc:MGI:2140804] |
| Ensembl ID | ENSMUSG00000034528 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 13 |
| Synonyms | AI047820, FLDP, HMFN0376, hydroxysteroid (17-beta) dehydrogenase 13, hydroxysteroid 17-beta dehydrogenase 13, hydroxysteroid (17-β) dehydrogenase 13, hydroxysteroid 17-β dehydrogenase 13, NIIL497, Pan1b, PAN1B-LIKE, SCDR9, SDR16C3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsd17b13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- SDR family mycofactocin-dependent oxidoreductase
- KR domain
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cirrhosis
- hepatocellular carcinoma
- epithelial cancer
- hepatic steatosis
- diabetes mellitus
- diet-induced nonalcoholic steatohepatitis
- nonalcoholic steatohepatitis
- hepatic fibrosis
- alcoholic liver disease
- microvesicular hepatic steatosis
role in cell
- binding in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- lipid droplets
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsd17b13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- positive regulation of lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- steroid dehydrogenase activity
- retinol dehydrogenase activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor