Morc2a Gene Summary [Mouse]
Enables histone binding activity. Involved in transposable element silencing by heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Morc2a |
| Official Name | microrchidia 2A [Source:MGI Symbol;Acc:MGI:1921772] |
| Ensembl ID | ENSMUSG00000034543 |
| Bio databases IDs | |
| Aliases | microrchidia 2A |
| Synonyms | 8430403M08Rik, CMT2Z, DIGFAN, microrchidia 2A, Morc2a, MORC family CW-type zinc finger 2, ZCW3, ZCWCC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Morc2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- CW-type Zinc Finger
- Histidine kinase-like ATPase domain
- ATP binding
- chromatin binding
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- ATPase
- Morc6 ribosomal protein S5 domain 2-like
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- zinc ion binding
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- Charcot-Marie-Tooth disease axonal type 2Z
- colorectal cancer
- COVID-19
- developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy
- polyglandular autoimmune syndrome type 1
- hereditary disorder
- neurodevelopmental disorder
- Leigh syndrome
phenotypes
- abnormal gait
- decreased fasting circulating glucose level
- increased mean corpuscular hemoglobin
- prenatal lethality prior to heart atrial septation
- preweaning lethality complete penetrance
- aberrant origin of the right subclavian artery
- abnormal Meckel's cartilage morphology
- abnormal Mullerian duct morphology
- abnormal Wolffian duct morphology
- abnormal Wolffian duct topology
- abnormal adrenal gland morphology
- abnormal anterior cerebral artery morphology
- abnormal atrioventricular cushion morphology
- abnormal brain internal capsule morphology
- abnormal brain morphology
- abnormal carpal bone morphology
- abnormal celiac artery morphology
- abnormal choroid plexus morphology
- abnormal clavicle morphology
- abnormal common bile duct morphology
- abnormal diaphragm morphology
- abnormal dorsal pancreas topology
- abnormal ductus venosus topology
- abnormal external auditory canal morphology
- abnormal eye muscle morphology
- abnormal facial nerve topology
- abnormal forebrain morphology
- abnormal forelimb morphology
- abnormal head morphology
- abnormal hindbrain morphology
- abnormal humerus morphology
- abnormal hyoid bone body morphology
- abnormal hypoglossal nerve topology
- abnormal incisor morphology
- abnormal inferior vena cava morphology
- abnormal infrahyoid muscle connection
- abnormal inner ear morphology
- abnormal interatrial septum morphology
- abnormal internal carotid artery topology
- abnormal intestine placement
- abnormal intrathoracic topology of vagus nerve
- abnormal jaw morphology
- abnormal left lung morphology
- abnormal lens morphology
- abnormal liver morphology
- abnormal liver vasculature morphology
- abnormal masticatory muscle morphology
- abnormal middle ear morphology
- abnormal middle ear ossicle morphology
- abnormal nasal cavity morphology
- abnormal nasal septum morphology
- abnormal occipital bone morphology
- abnormal olfactory bulb morphology
- abnormal olfactory bulb position
- abnormal olfactory nerve morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal pectinate muscle morphology
- abnormal pineal gland morphology
- abnormal pituitary gland morphology
- abnormal radius morphology
- abnormal rib morphology
- abnormal right lung morphology
- abnormal salivary gland morphology
- abnormal scapula morphology
- abnormal sphenoid bone morphology
- abnormal stapes morphology
- abnormal subclavian artery origin
- abnormal testis morphology
- abnormal thymus topology
- abnormal thyroid gland morphology
- abnormal ulna morphology
- abnormal ureter topology
- abnormal vertebral arch morphology
- abnormal vertebral artery origin
- abnormal vertebral body morphology
- abnormal vitelline vein connection
- abnormal vomeronasal organ morphology
- absent Mullerian ducts
- absent Wolffian ducts
- absent connection between subcutaneous lymph vessels and lymph sac
- absent digastric muscle
- absent ductus venosus valve
- absent external auditory canal
- absent eye muscles
- absent humerus
- absent intracranial segment of vertebral artery
- absent intrahepatic inferior vena cava segment
- absent mandibular nerve
- absent neurocranium
- absent occipital bone
- absent optic chiasm
- absent pituitary gland
- absent posterior communicating artery
- absent radius
- absent salivary gland
- absent segment of anterior cerebral artery
- absent stapedial artery
- absent superior cervical ganglion
- absent upper incisors
- absent ventral pancreas
- absent vertebral body
- aphakia
- athymia
- basisphenoid bone foramen
- blood in lymph vessels
- diaphragmatic hernia
- double inlet heart right ventricle
- double outlet right ventricle
- embryonic growth retardation
- enlarged brain ventricles
- facial cleft
- fragmented Meckel's cartilage
- heterochrony
- holoprosencephaly
- intracerebral hemorrhage
- left sided brachiocephalic trunk
- liver cysts
- muscular ventricular septal defect
- oligodactyly
- perimembraneous ventricular septal defect
- persistent dorsal ophthalmic artery
- persistent truncus arteriosis
- reduced sympathetic cervical ganglion size
- retro-esophageal left subclavian artery
- right aortic arch
- short tongue
- small adrenal glands
- small dorsal pancreas
- small kidney
- small ovary
- small pancreas
- small thymus
- small thyroid gland
- small trigeminal ganglion
- small ventral pancreas
- subcutaneous edema
- thoracoschisis
- tongue hypoplasia
- trigeminal neuroma
role in cell
- expression in
- proliferation
- phosphorylation in
- senescence
- cell proliferation
- G1 phase
- DNA damage response
- clonogenicity
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Morc2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of retroviral genome replication
- negative regulation of gene expression, epigenetic
- response to DNA damage stimulus
- positive regulation of methylation-dependent chromatin silencing
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- cytoplasm
- cytosol
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- zinc ion binding
- protein binding
- protein homodimerization activity
- chromatin binding