MORC2 Gene Summary [Human]
This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | MORC2 |
| Official Name | MORC family CW-type zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:23573] |
| Ensembl ID | ENSG00000133422 |
| Bio databases IDs | |
| Aliases | MORC family CW-type zinc finger 2 |
| Synonyms | 8430403M08Rik, CMT2Z, DIGFAN, microrchidia 2A, Morc2a, MORC family CW-type zinc finger 2, ZCW3, ZCWCC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MORC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- CW-type Zinc Finger
- Histidine kinase-like ATPase domain
- ATP binding
- chromatin binding
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- ATPase
- Morc6 ribosomal protein S5 domain 2-like
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- zinc ion binding
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- Charcot-Marie-Tooth disease axonal type 2Z
- colorectal cancer
- COVID-19
- developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy
- polyglandular autoimmune syndrome type 1
- hereditary disorder
- neurodevelopmental disorder
- Leigh syndrome
role in cell
- expression in
- proliferation
- phosphorylation in
- senescence
- cell proliferation
- G1 phase
- DNA damage response
- clonogenicity
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MORC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of retroviral genome replication
- negative regulation of gene expression, epigenetic
- response to DNA damage stimulus
- positive regulation of methylation-dependent chromatin silencing
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- cytoplasm
- cytosol
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- zinc ion binding
- protein binding
- protein homodimerization activity
- chromatin binding