Ttyh2 Gene Summary [Mouse]

Enables calcium ion binding activity and volume-sensitive chloride channel activity. Involved in L-glutamate transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; olfactory epithelium; retina layer; and submandibular gland primordium mesenchyme. Orthologous to human TTYH2 (tweety family member 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ttyh2
Official Name
tweety family member 2 [Source:MGI Symbol;Acc:MGI:2157091]
Ensembl ID
ENSMUSG00000034714
Bio databases IDs NCBI: 117160 Ensembl: ENSMUSG00000034714
Aliases tweety family member 2
Synonyms 1110001A03Rik, C17orf29, LOC100505117, RGD1562969, tweety family member 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttyh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • volume-sensitive anion channel
  • tweety N-terminal domain
  • chloride channel
  • calcium ion binding
  • protein binding
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
regulates
  • L-glutamic acid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttyh2 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • chloride channel complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • intracellular calcium activated chloride channel activity
  • calcium ion binding
  • volume-sensitive chloride channel activity
  • chloride channel activity
  • volume-sensitive anion channel activity

Gene-Specific Assays for Results You Can Trust

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