Cyp1a1 Gene Summary [Mouse]
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; response to toxic substance; and toxin metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; maxillary process; spleen; and upper jaw. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp1a1 |
| Official Name | cytochrome P450, family 1, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88588] |
| Ensembl ID | ENSMUSG00000032315 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 1, subfamily a, polypeptide 1 |
| Synonyms | AHH, AH Hydroxylase, AHRR, CP11, CYP1, CYPIA1, cytochrome P450 family 1 subfamily A member 1, cytochrome P450, family 1, subfamily a, polypeptide 1, EROD, P1-450, P450-1, P450-C, P450DX, P450-P1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- oxygen binding
- oxidoreductase
- heat shock protein binding
- enzyme binding
- heme binding domain
- enzyme
- protein binding
- steroid hydroxylase
- arachidonic acid monooxygenase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- flavonoid 3'-monooxygenase
- monooxygenase
- demethylase activity
- diphenol related substance oxidoreductase
Pathways
Biological processes and signaling networks where the Cyp1a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- epithelial cancer
- epithelial neoplasia
- cancer
- acute lymphoblastic leukemia
- weight loss
- COVID-19
- hepatocellular carcinoma
- liver cancer
- lung cancer
regulated by
- phenobarbital
- podocytes
- resveratrol
- HMOX1
- tretinoin
- prednisolone
- curcumin
- lipopolysaccharide
- quercetin
- N-acetyl-L-cysteine
role in cell
- expression in
- formation in
- proliferation
- loss
- activation in
- quantity
- growth
- binding in
- induction in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- microsome
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- response to food
- response to iron(III) ion
- long-chain fatty acid biosynthetic process
- ethylene metabolic process
- retinol metabolic process
- steroid metabolic process
- cellular response to copper ion
- flavonoid metabolic process
- response to herbicide
- vitamin D metabolic process
- omega-hydroxylase P450 pathway
- porphyrin-containing compound metabolic process
- coumarin metabolic process
- response to hypoxia
- amine metabolic process
- lipid hydroxylation
- response to arsenic-containing substance
- digestive tract development
- hepatocyte differentiation
- camera-type eye development
- dibenzo-p-dioxin catabolic process
- insecticide metabolic process
- estrogen metabolic process
- positive regulation of G1/S transition of mitotic cell cycle
- 9-cis-retinoic acid biosynthetic process
- steroid biosynthetic process
- nitric oxide metabolic process
- maternal process involved in parturition
- fatty acid metabolic process
- response to nematode
- tissue remodeling
- long-chain fatty acid metabolic process
- epoxygenase P450 pathway
- xenobiotic metabolic process
- response to lipopolysaccharide
- response to immobilization stress
- response to vitamin A
- cellular response to organic cyclic compound
- hydrogen peroxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- flavonoid 3'-monooxygenase activity
- oxidoreductase activity, acting on diphenols and related substances as donors
- arachidonic acid monooxygenase activity
- demethylase activity
- monooxygenase activity
- heme binding
- protein binding
- oxidoreductase activity
- iron ion binding
- aromatase activity
- Hsp90 protein binding
- vitamin D 24-hydroxylase activity
- Hsp70 protein binding
- enzyme binding