Rtkn Gene Summary [Mouse]
Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtkn |
| Official Name | rhotekin [Source:MGI Symbol;Acc:MGI:107371] |
| Ensembl ID | ENSMUSG00000034930 |
| Bio databases IDs | |
| Aliases | rhotekin |
| Synonyms | LOC103692165, RHOTEKIN, RTKN-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtkn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- p21 binding domain
- RNA recognition motif
- enzyme binding
- central domain
- protein binding
- Pleckstrin homology-like domain
- Cell division protein anillin
- GTPase inhibitor
- Ras-binding domain
- PH domain
- Rho-binding domain
- PDZ binding motif
- Hr1 repeat
- HR1
Pathways
Biological processes and signaling networks where the Rtkn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- expression in
- growth
- activation in
- quantity
- formation
- apoptosis
- cell death
- ruffling
- ruffling in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- vesicles
- cytosol
- nerve ending
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtkn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis, actomyosin contractile ring assembly
- signal transduction
- cytokinesis after mitosis
- apoptotic process
- regulation of apoptotic process
- Rho protein signal transduction
- septin ring organization
Cellular Component
Where in the cell the gene product is active
- actomyosin contractile ring
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase inhibitor activity
- small GTPase binding