Rassf1 Gene Summary [Mouse]
Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver; metanephros; and neural retina. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rassf1 |
| Official Name | Ras association (RalGDS/AF-6) domain family member 1 [Source:MGI Symbol;Acc:MGI:1928386] |
| Ensembl ID | ENSMUSG00000010067 |
| Bio databases IDs | |
| Aliases | Ras association (RalGDS/AF-6) domain family member 1 |
| Synonyms | 123F2, AA536941, AU044980, D4Mgi37, NORE2A, Ras association domain family member 1, Ras association (RalGDS/AF-6) domain family member 1, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rassf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- enzyme binding
- protein binding
- identical protein binding
- SARAH_SF
- ras association domain
- zinc ion binding
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- zinc finger domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Rassf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cirrhosis
- schizophrenia
- tumorigenesis
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- cutaneous melanoma
- hepatocellular carcinoma
- mammary neoplasm
role in cell
- phosphorylation in
- cell viability
- proliferation
- expression in
- morphology
- survival
- growth
- degradation in
- cell death
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- extranuclear space
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- Plasma Membrane
- centrosome
- Mitochondria
- microtubules
- midbody
- microtubule organizing centers
- cytosol
- inner nuclear membrane
- spindle pole
- spindle fibers
- nuclear envelope
- cytoplasmic microtubule
- astral microtubules
- PML nuclear bodies
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rassf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- centrosome
- cytoplasm
- spindle pole
- microtubule
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding