Prkd3 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; integumental system; musculoskeletal system; and retina. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkd3 |
| Official Name | protein kinase D3 [Source:MGI Symbol;Acc:MGI:1922542] |
| Ensembl ID | ENSMUSG00000024070 |
| Bio databases IDs | |
| Aliases | protein kinase D3 |
| Synonyms | 4930557O20Rik, 5730497N19Rik, EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN, protein kinase D3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- PH domain
- protein kinase C
- Pleckstrin homology-like domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkd3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- ErbB4 Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- prostatic neoplasm
- prostatic neoplasia
- Alzheimer disease
- gastric adenocarcinoma
- gastric epithelial cancer
- eosinophilic esophagitis
- dementia
role in cell
- proliferation
- generation
- apoptosis
- activation in
- expression in
- differentiation
- signaling in
- phosphorylation in
- accumulation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipase C-activating G-protein coupled receptor signaling pathway
- protein kinase C-activating G-protein coupled receptor signaling pathway
- protein phosphorylation
- intracellular signal transduction
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity
- kinase activity
- protein kinase C activity