Tmem106a Gene Summary [Mouse]
Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and positive regulation of nitric oxide metabolic process. Located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem106a |
| Official Name | transmembrane protein 106A [Source:MGI Symbol;Acc:MGI:1922056] |
| Ensembl ID | ENSMUSG00000034947 |
| Bio databases IDs | |
| Aliases | transmembrane protein 106A |
| Synonyms | 0610008L10RIK, AI043106, BC022145, FLJ77644, RGD1309043, transmembrane protein 106A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem106a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1356)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem106a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CD86 biosynthetic process
- innate immune response
- CD80 biosynthetic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of tumor necrosis factor production
- positive regulation of MAPK cascade
- positive regulation of interleukin-6 production
- positive regulation of MHC class II biosynthetic process
- macrophage activation
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding