Scnn1a Gene Summary [Mouse]
Enables WW domain binding activity. Contributes to sodium channel activity. Involved in intracellular sodium ion homeostasis and sodium ion import across plasma membrane. Acts upstream of or within cellular response to aldosterone and sodium ion transport. Located in cytosol and external side of plasma membrane. Part of sodium channel complex. Is expressed in several structures, including colon; heart; hindgut; liver; and lung. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (sodium channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scnn1a |
| Official Name | sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782] |
| Ensembl ID | ENSMUSG00000030340 |
| Bio databases IDs | |
| Aliases | sodium channel, nonvoltage-gated 1 alpha |
| Synonyms | Alpha-ENaC, alphaEnNaC, BESC2, ENaC, ENaCA, ENaC-alpha, ENaC-α, Epithelial amiloride sensitive Na+ channel α, LIDLS3, mENaC, PHA1B1, SCNEA, SCNN1, sodium channel epithelial 1 subunit alpha, sodium channel epithelial 1 subunit α, sodium channel, nonvoltage-gated 1 alpha, sodium channel, nonvoltage-gated 1 α, α-ENaC, αEnNaC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scnn1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium channel
- sodium ion transporter
- amiloride-sensitive sodium channel
- WW domain binding
- protein binding
- thumb domain
- proline tyrosine motif
- ion channel
- degenerin
- ubiquitin binding domain
- actin binding
- sodium channel transporter
- intracellular domain
- tail domain
Pathways
Biological processes and signaling networks where the Scnn1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- resistant hypertension
- autosomal recessive pseudohypoaldosteronism type IB1
- edema
- cardiovascular disorder
- autosomal recessive pseudohypoaldosteronism type I
- prehypertension
- acidosis
- congestive heart failure
- essential hypertension
role in cell
- cell viability
- migration
- whole-cell conductance
- invasion by
- migration by
- response by
- activation in
- volume
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- sperm membranes
- cortical actin cytoskeleton
- Cytoplasm
- cilia
- intracellular space
- cellular membrane
- cytosol
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- acrosome
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scnn1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal water homeostasis
- sensory perception of sour taste
- sodium ion homeostasis
- cellular response to acidity
- cellular sodium ion homeostasis
- sensory perception of salty taste
- sodium ion transmembrane transport
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- sodium channel complex
- motile cilium
- extracellular vesicular exosome
- cytoplasm
- acrosomal vesicle
- external side of plasma membrane
- sperm principal piece
- cytosol
- cilium membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-gated sodium channel activity
- WW domain binding