Tyrobp Gene Summary [Mouse]
Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tyrobp |
| Official Name | TYRO protein tyrosine kinase binding protein [Source:MGI Symbol;Acc:MGI:1277211] |
| Ensembl ID | ENSMUSG00000030579 |
| Bio databases IDs | |
| Aliases | TYRO protein tyrosine kinase binding protein |
| Synonyms | DAP12, KARAP, Ly83, PLOSL, PLOSL1, transmembrane immune signaling adaptor TYROBP, Tyro, TYRO protein tyrosine kinase binding protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tyrobp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- transmembrane domain
- protein binding activity, bridging
- intracellular domain
- protein homodimerization
- protein binding
- receptor binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tyrobp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- osteopetrosis
- hypomyelination
- diabetic nephropathy
- osteopenia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy type 1
- experimental autoimmune encephalomyelitis
- laser induced choroidal neovascularization
role in cell
- expression in
- apoptosis
- proliferation
- survival
- quantity
- formation in
- differentiation
- cytotoxicity
- activation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tyrobp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of long-term synaptic potentiation
- negative regulation of interleukin-10 production
- microglial cell activation involved in immune response
- neutrophil activation involved in immune response
- response to axon injury
- stimulatory killer cell immunoglobulin-like receptor signaling pathway
- stimulatory C-type lectin receptor signaling pathway
- negative regulation of B cell proliferation
- forebrain development
- positive regulation of tumor necrosis factor production
- positive regulation of osteoclast development
- intracellular signal transduction
- negative regulation of type I interferon production
- positive regulation of protein localization at cell surface
- signal transduction
- positive regulation of macrophage fusion
- apoptotic cell clearance
- myeloid leukocyte activation
- osteoclast differentiation
- cellular defense response
- negative regulation of transforming growth factor beta1 production
- positive regulation of gene expression
- positive regulation of natural killer cell activation
- protein stabilization
- positive regulation of interleukin-6 production
- actin cytoskeleton organization
- positive regulation of interleukin-1 beta production
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- metal ion binding
- receptor binding
- binding, bridging