Dapk3 Gene Summary [Mouse]
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including cellular response to type II interferon; protein phosphorylation; and regulation of myosin II filament organization. Acts upstream of or within apoptotic signaling pathway. Located in PML body. Is expressed in heart; mammary gland epithelium; and notochord. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dapk3 |
| Official Name | death-associated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1203520] |
| Ensembl ID | ENSMUSG00000034974 |
| Bio databases IDs | |
| Aliases | death-associated protein kinase 3 |
| Synonyms | DAP kinase 3, DAPKL, death-associated protein kinase 3, DLK, MYPTK1, ZIP, ZIPK, Zip kinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dapk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- cAMP response element binding protein binding
- Protein tyrosine and serine/threonine kinase
- LRR-domain binding
- ATP binding
- enzyme binding
- transcription factor binding
- leucine zipper domain
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Dapk3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- T-cell non-Hodgkin disease
- behavioral deficit
- monomorphic epitheliotropic intestinal T-cell lymphoma
- mature T-cell neoplasia
- brain edema
- primary open-angle glaucoma
- type I enteropathy-associated T-cell lymphoma
role in cell
- cell viability
- expression in
- phosphorylation in
- apoptosis
- binding in
- autophagy by
- growth
- inhibition in
- signaling in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- spindle apparatus
- cilia
- Nucleus
- actin filaments
- midbody
- cytosol
- nucleoplasm
- membrane rafts
- PML nuclear bodies
- centromeres
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dapk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of mitosis
- regulation of myosin II filament organization
- positive regulation of canonical Wnt receptor signaling pathway
- protein autophosphorylation
- apoptotic signaling pathway
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- chromatin organization
- protein phosphorylation
- regulation of mitotic cell cycle
- regulation of smooth muscle contraction
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- regulation of autophagy
- apoptotic process
- positive regulation of apoptotic process
- regulation of cell motility
- cellular response to interferon-gamma
- negative regulation of translation
- intracellular signal transduction
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- small GTPase binding
- protein serine/threonine kinase activity
- leucine zipper domain binding