Myl6 Gene Summary [Mouse]
Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Part of unconventional myosin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl6 |
| Official Name | myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [Source:MGI Symbol;Acc:MGI:109318] |
| Ensembl ID | ENSMUSG00000090841 |
| Bio databases IDs | |
| Aliases | myosin, light polypeptide 6, alkali, smooth muscle and non-muscle |
| Synonyms | ESMLC, LC17, LC17-GI, LC17-NM, LOC684520, MLC1SM, MLC-3, MLC3NM, MLC3SM, Myl6l, MYLN, myosin light chain 6, Myosin light chain, alkali, nonmuscle, myosin, light polypeptide 6, alkali, smooth muscle and non-muscle, Myosin NonMuscle p-Light Chain, MYOSIN SMOOTH MUSCLE P-LIGHT CHAIN, Smooth Muscle Myosin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- structural constituent of muscle
- EF hand
- microfilament motor protein
- EFh
- enzyme
- protein binding
- motor protein
Pathways
Biological processes and signaling networks where the Myl6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- Leukocyte Extravasation Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- Nucleus
- Plasma Membrane
- cytosol
- synaptic vesicles
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle tissue development
- muscle contraction
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- myosin complex
- extracellular vesicular exosome
- brush border
- membrane
- myosin II complex
- unconventional myosin complex
- cytosol
- vesicle
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- protein binding
- calcium ion binding
- microfilament motor activity
- motor activity