Ncapd3 Gene Summary [Mouse]
Predicted to enable methylated histone binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of or within meiotic chromosome separation. Located in condensed nuclear chromosome; germinal vesicle; and kinetochore. Part of condensin complex. Is expressed in cerebral cortex subventricular zone. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 22. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ncapd3 |
| Official Name | non-SMC condensin II complex, subunit D3 [Source:MGI Symbol;Acc:MGI:2142989] |
| Ensembl ID | ENSMUSG00000035024 |
| Bio databases IDs | |
| Aliases | non-SMC condensin II complex, subunit D3 |
| Synonyms | 2810487N22Rik, 4632407J06Rik, B130055D15RIK, CAP-D3, hCAP-D3, HCP-6, hHCP-6, KIAA0056, MCPH22, MGC104671, mKIAA0056, non-SMC condensin II complex subunit D3, non-SMC condensin II complex, subunit D3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncapd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- non-SMC mitotic condensation complex subunit 1
- histone binding
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- major depression
- autosomal recessive primary microcephaly type 22
- organismal death
- preeclampsia
- bronchiectasis
- azoxymethane/dextran sodium sulfate induced colorectal cancer
role in cell
- expression in
- quantity
- segregation
- appearance
- binding in
- appearance in
- alignment
- chromosome condensation in
- resolution in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- germinal vesicles
- kinetochores
- centromeres
- chromosomal arms
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncapd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- membrane
- condensed chromosome, centromeric region
- condensin complex
- centromeric heterochromatin
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- methylated histone residue binding