Ncapd3 Gene Summary [Rat]
Predicted to enable methylated histone binding activity. Predicted to be involved in chromosome condensation and regulation of chromosome segregation. Predicted to act upstream of or within meiotic chromosome separation. Predicted to be located in chromosome and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 22. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncapd3 |
| Official Name | non-SMC condensin II complex, subunit D3 [Source:RGD Symbol;Acc:1562176] |
| Ensembl ID | ENSRNOG00000008932 |
| Bio databases IDs | |
| Aliases | non-SMC condensin II complex, subunit D3 |
| Synonyms | 2810487N22Rik, 4632407J06Rik, B130055D15RIK, CAP-D3, hCAP-D3, HCP-6, hHCP-6, KIAA0056, MCPH22, MGC104671, mKIAA0056, non-SMC condensin II complex subunit D3, non-SMC condensin II complex, subunit D3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncapd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- non-SMC mitotic condensation complex subunit 1
- histone binding
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- major depression
- autosomal recessive primary microcephaly type 22
- organismal death
- preeclampsia
- bronchiectasis
- azoxymethane/dextran sodium sulfate induced colorectal cancer
role in cell
- expression in
- quantity
- segregation
- appearance
- binding in
- appearance in
- alignment
- chromosome condensation in
- resolution in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- germinal vesicles
- kinetochores
- centromeres
- chromosomal arms
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncapd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- membrane
- condensed chromosome, centromeric region
- condensin complex
- centromeric heterochromatin
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- methylated histone residue binding