Leprot Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; heart valve; and retina nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Leprot |
| Official Name | leptin receptor overlapping transcript [Source:MGI Symbol;Acc:MGI:2687005] |
| Ensembl ID | ENSMUSG00000035212 |
| Bio databases IDs | |
| Aliases | leptin receptor overlapping transcript |
| Synonyms | Endo1', Endospanin1, LEPR, leptin receptor overlapping transcript, OB-RGRP, VPS55 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Leprot often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar protein sorting 55
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Leprot gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization at cell surface
- negative regulation of growth hormone receptor signaling pathway
- late endosome to vacuole transport via multivesicular body sorting pathway
- negative regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- endosome
- Golgi membrane
- endosome membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding