Spcs2 Gene Summary [Mouse]
Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and urinary system. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spcs2 |
| Official Name | signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874] |
| Ensembl ID | ENSMUSG00000035227 |
| Bio databases IDs | |
| Aliases | signal peptidase complex subunit 2 homolog (S. cerevisiae) |
| Synonyms | 5730406I15Rik, KIAA0102, mKIAA0102, RGD1311253, signal peptidase complex subunit 2, signal peptidase complex subunit 2 homolog (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spcs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microsomal signal peptidase 25 kDa subunit (SPC25)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- endoplasmic reticulum membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spcs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal peptide processing
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- signal peptidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding