Pkig Gene Summary [Mouse]
Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pkig |
| Official Name | protein kinase inhibitor, gamma [Source:MGI Symbol;Acc:MGI:1343086] |
| Ensembl ID | ENSMUSG00000035268 |
| Bio databases IDs | |
| Aliases | protein kinase inhibitor, gamma |
| Synonyms | cAMP-dependent protein kinase inhibitor gamma, cAMP-dependent protein kinase inhibitor γ, PKI-gamma, PKI-γ, protein kinase inhibitor, gamma, protein kinase inhibitor, γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkig often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cAMP-dependent protein kinase inhibitor
- cAMP-dependent protein kinase inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the Pkig gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Rett syndrome
- pelvic organ prolapse
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- PRKACA
role in cell
- differentiation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkig gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cAMP-dependent protein kinase activity
- negative regulation of protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cAMP-dependent protein kinase inhibitor activity