Tyms Gene Summary [Mouse]
This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tyms |
| Official Name | thymidylate synthase [Source:MGI Symbol;Acc:MGI:98878] |
| Ensembl ID | ENSMUSG00000025747 |
| Bio databases IDs | |
| Aliases | thymidylate synthase |
| Synonyms | DKCD, HST422, thymidylate synthase, thymidylate synthetase, TMS, TS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tyms often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thymidylate synthase
- binding protein
- folic acid binding
- mRNA binding
- nucleic acid binding translation repressor
- protein homodimerization
- enzyme
- TS_Pyrimidine_HMase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microsatellite instability high colon cancer
- rectum cancer
- advanced colon cancer
- metastatic colon cancer
- metastatic rectal cancer
- metastatic colorectal cancer
- advanced rectal cancer
- secondary neoplasm
- chronic lymphocytic leukemia
- metastatic gastric adenocarcinoma
role in cell
- apoptosis
- cell death
- growth
- cell cycle progression
- quantity
- proliferation
- survival
- translation in
- josamycin sensitivity
- pemetrexed sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tyms gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- intestinal epithelial cell maturation
- response to progesterone stimulus
- dTMP biosynthetic process
- response to xenobiotic stimulus
- developmental growth
- circadian rhythm
- response to toxin
- dTTP biosynthetic process
- response to ethanol
- response to glucocorticoid stimulus
- response to folic acid
- response to organophosphorus
- DNA biosynthetic process
- uracil metabolic process
- tetrahydrofolate interconversion
- response to vitamin A
- negative regulation of translation
- methylation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- thymidylate synthase activity
- protein homodimerization activity
- translation repressor activity, nucleic acid binding
- folic acid binding