Plekhj1 Gene Summary [Mouse]
Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Is expressed in brain; gonad; liver; musculature; and spleen. Orthologous to human PLEKHJ1 (pleckstrin homology domain containing J1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Plekhj1 |
| Official Name | pleckstrin homology domain containing, family J member 1 [Source:MGI Symbol;Acc:MGI:1925920] |
| Ensembl ID | ENSMUSG00000035278 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family J member 1 |
| Synonyms | 9530063M10Rik, GNRPX, pleckstrin homology domain containing, family J member 1, pleckstrin homology domain containing J1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhj1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhj1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- retrograde transport, endosome to Golgi
- receptor recycling
Cellular Component
Where in the cell the gene product is active
- early endosome
- trans-Golgi network
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- protein binding