Stab2 Gene Summary [Mouse]
Enables cargo receptor activity. Involved in hyaluronan catabolic process and receptor-mediated endocytosis. Predicted to be located in cytosol and external side of plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; heart; and liver. Orthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stab2 |
| Official Name | stabilin 2 [Source:MGI Symbol;Acc:MGI:2178743] |
| Ensembl ID | ENSMUSG00000035459 |
| Bio databases IDs | |
| Aliases | stabilin 2 |
| Synonyms | FEEL-2, FELE-2, FELL, FELL2, FEX2, HARE, MFEEL-2, RGD1560941, SCARH1, STABILIN-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- ectodomain
- low-density lipoprotein binding
- Extracellular link domain
- protein binding
- EGF_CA
- NPXY motif
- Fasciclin domain
- FAS1 domain
- endocytic domain
- scavenger receptor
- Link_Domain
- EGF domain
- cytosolic tail domain
- low-density lipoprotein receptor
- hyaluronic acid binding
- transmembrane receptor
- EGF repeat
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- coronary artery disease
- ischemic stroke
- schizoaffective disorder bipolar subtype
- congestion
- congestive heart failure
- metastasis
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
role in cell
- activation in
- migration
- phagocytosis
- endocytosis by
- phagocytosis by
- sprouting angiogenesis by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- intracellular compartment
- cell surface
- intracellular space
- granules
- cytosol
- plasma membrane extracellular face
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- cell adhesion
- endocytosis
- receptor-mediated endocytosis
- defense response to bacterium
- defense response to Gram-positive bacterium
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- cytosol
- plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein disulfide oxidoreductase activity
- protein binding
- calcium ion binding
- low-density lipoprotein receptor activity
- scavenger receptor activity
- hyaluronic acid binding
- low-density lipoprotein particle binding