Lipa Gene Summary [Mouse]
Predicted to enable sterol ester esterase activity. Acts upstream of or within several processes, including ATP metabolic process; hematopoietic or lymphoid organ development; and hemopoiesis. Is active in lysosome. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Used to study Wolman disease and lysosomal acid lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease and cholesterol ester storage disease. Orthologous to human LIPA (lipase A, lysosomal acid type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lipa |
| Official Name | lysosomal acid lipase A [Source:MGI Symbol;Acc:MGI:96789] |
| Ensembl ID | ENSMUSG00000024781 |
| Bio databases IDs | |
| Aliases | lysosomal acid lipase A |
| Synonyms | Aceh, CEH, CESD, Chole, Chole2, Cholesteryl ester hydrolase, LAL, LIP1, Lipase A, lipase A, lysosomal acid type, lysosomal acid lipase A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lipa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- sterol esterase
- alpha/beta hydrolases
- Partial alpha/beta-hydrolase lipase region
- lipase
- enzyme
Pathways
Biological processes and signaling networks where the Lipa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- heart disease
- COVID-19
- neoplasia
- breast cancer
- lysosomal acid lipase deficiency
- Wolman disease
- coronary artery disease
- ischemic stroke
- gastric adenocarcinoma
phenotypes
- abnormal Kupffer cell morphology
- abnormal adrenal gland morphology
- abnormal alveolar macrophage morphology
- abnormal brown adipose tissue morphology
- abnormal choroid plexus morphology
- abnormal duodenum morphology
- abnormal hepatocyte morphology
- abnormal inguinal fat pad morphology
- abnormal interscapular fat pad morphology
- abnormal intestinal mucosa morphology
- abnormal intestine morphology
- abnormal jejunum morphology
- abnormal lipid level
- abnormal liver morphology
- abnormal liver sinusoid morphology
- abnormal lung morphology
- abnormal pulmonary alveolus morphology
- abnormal retroperitoneal fat pad morphology
- abnormal small intestinal villus morphology
- abnormal small intestine morphology
- abnormal spleen morphology
- abnormal type II pneumocyte morphology
- abnormal white fat cell size
- absent subcutaneous adipose tissue
- chronic inflammation
- decreased body weight
- decreased brown adipose tissue amount
- decreased circulating HDL cholesterol level
- decreased epididymal fat pad weight
- decreased subcutaneous adipose tissue amount
- decreased white adipose tissue amount
- emphysema
- enlarged mesenteric lymph nodes
- enlarged spleen
- hepatic steatosis
- hepatosplenomegaly
- increased brown fat cell lipid droplet size
- increased circulating LDL cholesterol level
- increased circulating free fatty acid level
- increased circulating insulin level
- increased club cell number
- increased food intake
- increased liver cholesterol level
- increased liver triglyceride level
- increased liver weight
- increased spleen weight
- increased type II pneumocyte number
- insulin resistance
- lung inflammation
- pale kidney
- premature death
role in cell
- expression in
- number
- proliferation
- organization
- binding in
- adhesion
- apoptosis
- production in
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- intracellular membrane-bounded organelle
- cellular membrane
- lysosome
- cytosol
- microsome
- lysosomal compartment
- nucleoplasm
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lipa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of adult lifespan
- triglyceride metabolic process
- glucose metabolic process
- hemopoietic progenitor cell differentiation
- regulation of mitochondrial membrane potential
- defecation
- low-density lipoprotein particle clearance
- small GTPase mediated signal transduction
- cell morphogenesis
- glycolysis
- cholesterol biosynthetic process
- endocytosis
- vitamin A metabolic process
- T cell differentiation
- tissue remodeling
- blood vessel endothelial cell differentiation
- liver morphogenesis
- acute inflammatory response
- lipid catabolic process
- T cell apoptotic process
- myeloid cell differentiation
- gene expression
- sterol metabolic process
- cell proliferation in bone marrow
- spleen development
- response to xenobiotic stimulus
- response to dietary excess
- lipoprotein catabolic process
- bone marrow development
- mitotic cell cycle
- response to cold
- respiratory burst involved in inflammatory response
- cholesterol storage
- fat cell proliferation
- triglyceride-rich lipoprotein particle clearance
- lung development
- lysosome organization
- lipid homeostasis
- endosome to lysosome transport
- TOR signaling cascade
- ATP biosynthetic process
- mitochondrion organization
- fatty acid metabolic process
- adipose tissue development
- positive regulation of T cell receptor signaling pathway
- homeostasis of number of cells within a tissue
- T cell proliferation
- endothelial cell proliferation
- cholesterol efflux
- response to vitamin A
- common myeloid progenitor cell proliferation
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- lysosomal lumen
- fibrillar center
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- sterol esterase activity
- lipase activity