Tmsb4x Gene Summary [Mouse]
Predicted to enable actin monomer binding activity; enzyme binding activity; and protein sequestering activity. Acts upstream of or within regulation of cell migration. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart and pericardium; and tooth. Orthologous to human TMSB4X (thymosin beta 4 X-linked). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmsb4x |
| Official Name | thymosin, beta 4, X chromosome [Source:MGI Symbol;Acc:MGI:99510] |
| Ensembl ID | ENSMUSG00000049775 |
| Bio databases IDs | |
| Aliases | thymosin, beta 4, X chromosome |
| Synonyms | FX, PTMB4, Tb4, TB4X, T beta 4, THYB4, Thymosin beta 4, X chromosome, thymosin, beta 4, X chromosome, thymosin beta 4 X-linked, thymosin beta 4, X-linked, Thymosin β 4, Thymosin β 4x, Thymosin β 4, X chromosome, thymosin, β 4, X chromosome, thymosin β 4 X-linked, thymosin β 4, X-linked, TMSB4, T β 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmsb4x often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin-binding domain
- WH2
- thymosin beta domain
- actin monomer binding
- enzyme binding
- protein binding
- Thymosin beta-4 family
Pathways
Biological processes and signaling networks where the Tmsb4x gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- epithelial neoplasia
- albuminuria
- Alzheimer disease
- chronic sinusitis
- pancreatic intraductal papillary mucinous neoplasm
- pancreatic neoplasia
- endometriosis
- bleeding
- essential thrombocythemia
role in cell
- expression in
- migration
- differentiation
- chemotaxis
- apoptosis
- morphology
- phosphorylation in
- growth
- cell viability
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
- nuclear envelope
- alpha granules
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmsb4x gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- sequestering of actin monomers
- negative regulation of inflammatory response
- positive regulation of ATP biosynthetic process
- positive regulation of endothelial cell chemotaxis
- actin filament organization
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of cell migration
- positive regulation of blood vessel endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- actin monomer binding
- enzyme binding