Aldh1b1 Gene Summary [Mouse]
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in ethanol catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; and liver. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh1b1 |
| Official Name | aldehyde dehydrogenase 1 family, member B1 [Source:MGI Symbol;Acc:MGI:1919785] |
| Ensembl ID | ENSMUSG00000035561 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 1 family, member B1 |
| Synonyms | 2700007F14Rik, Aldehyde Dehydrogenase 1 B1, aldehyde dehydrogenase 1 family member B1, aldehyde dehydrogenase 1 family, member B1, ALDH1B, ALDH5, ALDHX, MITOCHONDRIAL ALDEHYDE DEHYDROGENASE X |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldh1b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- NAD or NADH binding
- betaine-aldehyde dehydrogenase
- aldehyde dehydrogenase (NAD)
- enzyme
- methylmalonic acid semialdehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh1b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aldh1b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- ethanol catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- NAD binding