Chrna5 Gene Summary [Mouse]
Predicted to enable acetylcholine binding activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within response to nicotine. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is expressed in several structures, including brain; gut; lung; trigeminal nerve; and vagus ganglion. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cocaine abuse; esophagus squamous cell carcinoma; nicotine dependence; and respiratory system cancer (multiple). Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna5 |
| Official Name | cholinergic receptor, nicotinic, alpha polypeptide 5 [Source:MGI Symbol;Acc:MGI:87889] |
| Ensembl ID | ENSMUSG00000035594 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, alpha polypeptide 5 |
| Synonyms | Acra-5, alpha5 ACHR, alpha5 NACHR, alpha5 NICOTINIC receptor, cholinergic receptor nicotinic alpha 5 subunit, cholinergic receptor, nicotinic, alpha polypeptide 5, cholinergic receptor nicotinic α 5 subunit, cholinergic receptor, nicotinic, α polypeptide 5, LNCR2, nAChR alpha5, sialoprotein, α5 nAChR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrna5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- acetylcholine receptor
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- acetylcholine binding
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrna5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- non-small cell lung cancer
- small cell lung cancer
- squamous cell lung cancer
- bladder cancer
- transitional cell bladder cancer
- renal cell cancer
- gallbladder disease
- chronic obstructive pulmonary disease
- lung cancer
role in cell
- expression in
- transactivation in
- proliferation
- activity
- migration
- firing
- response by
- excitation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrna5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- behavioral response to nicotine
- signal transduction
- ion transmembrane transport
- synaptic transmission
- response to nicotine
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor activity
- ligand-gated ion channel activity
- acetylcholine-gated cation channel activity