Rsf1 Gene Summary [Mouse]
Predicted to enable histone binding activity. Predicted to be involved in several processes, including nucleosome assembly; positive regulation of viral transcription; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of RSF complex. Is expressed in several structures, including ear; genitourinary system; and nervous system. Orthologous to human RSF1 (remodeling and spacing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rsf1 |
| Official Name | remodeling and spacing factor 1 [Source:MGI Symbol;Acc:MGI:2682305] |
| Ensembl ID | ENSMUSG00000035623 |
| Bio databases IDs | |
| Aliases | remodeling and spacing factor 1 |
| Synonyms | 4832420A03Rik, C030033M12RIK, Gm164, HBXAP, p325, remodeling and spacing factor 1, XAP8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rsf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- PHD finger superfamily
- protein binding
- WSTF, HB1, Itc1p, MBD9 motif 1
- DNA dependent ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- cell viability
- assembly
- organization
- remodeling
- remodeling in
- transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rsf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- transcription initiation, DNA-dependent
- chromatin organization
- positive regulation of viral transcription
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- RSF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding
- metal ion binding
- histone binding