Bbs10 Gene Summary [Mouse]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including neuronal action potential; retina morphogenesis in camera-type eye; and visual perception. Predicted to be located in cilium. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; pituitary gland; and respiratory system. Used to study Bardet-Biedl syndrome 10. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 10. Orthologous to human BBS10 (Bardet-Biedl syndrome 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Bbs10 |
| Official Name | Bardet-Biedl syndrome 10 (human) [Source:MGI Symbol;Acc:MGI:1919019] |
| Ensembl ID | ENSMUSG00000035759 |
| Bio databases IDs | |
| Aliases | Bardet-Biedl syndrome 10 (human) |
| Synonyms | 1300007O09Rik, Bardet-Biedl syndrome 10, C12orf58, RGD1560748 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bbs10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Bardet-Biedl syndrome
- Bardet-Biedl syndrome type 10
- digenic short rib thoracic dysplasia 3/6 with polydactyly
- obesity
- retinal dystrophy
- retinitis pigmentosa
- microalbuminuria
- hereditary disorder
- Bardet-Biedl syndrome type 1
- digenic Bardet-Biedl syndrome 1/10
role in cell
- cell death
- number
- apoptosis
- accumulation in
- degeneration
- differentiation
- assembly
- abnormal morphology
- lack
- electrophysiology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bbs10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- photoreceptor cell maintenance
- chaperone-mediated protein complex assembly
- regulation of protein complex assembly
- visual perception
Cellular Component
Where in the cell the gene product is active
- cilium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding