Frzb Gene Summary [Mouse]
Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway; neural crest cell differentiation; and somite development. Acts upstream of or within several processes, including cochlea morphogenesis; negative regulation of canonical Wnt signaling pathway; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frzb |
| Official Name | frizzled-related protein [Source:MGI Symbol;Acc:MGI:892032] |
| Ensembl ID | ENSMUSG00000027004 |
| Bio databases IDs | |
| Aliases | frizzled-related protein |
| Synonyms | FRE, frezzled, FRITZ, frizzled-related protein, Frp, FRP-3, FRZB-1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frzb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Wnt-protein binding
- Fz domain
- protein binding
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Frzb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- systemic lupus erythematosus
- plaque psoriasis
- osteoarthritis susceptibility 1
- HER2 negative hormone receptor negative breast cancer
- uterine serous papillary cancer
- epithelial cancer
- osteoarthritis
- malignant mesothelioma
- mesothelioma formation
role in cell
- activation
- proliferation
- development
- differentiation
- apoptosis
- cell death
- generation
- growth
- formation
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frzb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cartilage development
- neural crest cell differentiation
- somite development
- cochlea morphogenesis
- negative regulation of cell proliferation
- positive regulation of fat cell differentiation
- epithelial cell development
- convergent extension involved in organogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- skeletal system development
- negative regulation of cell growth
- hepatocyte differentiation
- positive regulation of apoptotic process
- negative regulation of cell development
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of hepatocyte differentiation
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- Wnt-protein binding