Rnf126 Gene Summary [Mouse]
Enables epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and protein K63-linked ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf126 |
| Official Name | ring finger protein 126 [Source:MGI Symbol;Acc:MGI:1917544] |
| Ensembl ID | ENSMUSG00000035890 |
| Bio databases IDs | |
| Aliases | ring finger protein 126 |
| Synonyms | 2610010O19RIK, FLJ20552, ring finger protein 126 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf126 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- epidermal growth factor receptor binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- zinc-ribbon
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- prostate cancer
- arterial stiffening
role in cell
- proliferation
- cell viability
- expression in
- activation in
- binding in
- sensitivity
- amplitude
- DNA damage repair in
- stabilization in
- homologous recombination dependent double-stranded DNA break repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf126 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
- retrograde transport, endosome to Golgi
- negative regulation of epidermal growth factor receptor signaling pathway
- protein K27-linked ubiquitination
- protein monoubiquitination
- regulation of cell proliferation
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- protein K29-linked ubiquitination
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein K63-linked ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- epidermal growth factor receptor binding