Gramd4 Gene Summary [Mouse]
Involved in negative regulation of toll-like receptor 9 signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human GRAMD4 (GRAM domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gramd4 |
| Official Name | GRAM domain containing 4 [Source:MGI Symbol;Acc:MGI:2676308] |
| Ensembl ID | ENSMUSG00000035900 |
| Bio databases IDs | |
| Aliases | GRAM domain containing 4 |
| Synonyms | 9930016O13, DIP, GRAM domain containing 4, KIAA0767, RGD1309983 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gramd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gramd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- apoptotic process
- negative regulation of toll-like receptor 9 signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding