Pold1 Gene Summary [Mouse]
Enables 3'-5' exonuclease activity and enzyme binding activity. Involved in DNA biosynthetic process. Acts upstream of or within DNA replication proofreading and base-excision repair, gap-filling. Part of delta DNA polymerase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pold1 |
| Official Name | polymerase (DNA directed), delta 1, catalytic subunit [Source:MGI Symbol;Acc:MGI:97741] |
| Ensembl ID | ENSMUSG00000038644 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), delta 1, catalytic subunit |
| Synonyms | CDC2, CRCS10, DNA POLYD, DNA POLYMERASE delta, DNA polymerase delta 1, catalytic subunit, DNA POLYMERASE δ, DNA polymerase δ 1, catalytic subunit, IMD120, MDPL, POLD, polymerase (DNA directed), delta 1, catalytic subunit, polymerase (DNA directed), δ 1, catalytic subunit, pol δ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pold1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exonuclease
- DNA-directed DNA polymerase
- DNA polymerase type-B family
- enzyme binding
- central domain
- chromatin binding
- enzyme
- protein binding
- DNA polymerase family B
- DNA binding
- POLBc
- C4-type zinc-finger of DNA polymerase delta
- DNA polymerase family B, exonuclease domain
- damaged DNA binding
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- active site
Pathways
Biological processes and signaling networks where the Pold1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- plasma cell myeloma
- infection
- neutropenia
- epithelial cancer
- epithelial neoplasia
- lipodystrophy
- liver cancer
- digestive system cancer
role in cell
- proliferation
- cell death
- cell viability
- mitosis
- formation
- DNA damage response in
- formation in
- mutagenesis in
- cell cycle progression in
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleolar fraction
- aggresome
- cytosol
- nuclear foci
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pold1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- fatty acid homeostasis
- DNA-dependent DNA replication
- nucleotide-excision repair, DNA gap filling
- response to UV
- DNA replication proofreading
- base-excision repair, gap-filling
- DNA synthesis involved in DNA repair
- DNA biosynthetic process
- cellular response to UV
- error-free translesion synthesis
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- delta DNA polymerase complex
- nucleotide-excision repair complex
- membrane
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- 3'-5'-exodeoxyribonuclease activity
- 4 iron, 4 sulfur cluster binding
- chromatin binding
- damaged DNA binding
- enzyme binding