Zfp57 Gene Summary [Mouse]
Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within epigenetic programming in the zygotic pronuclei; genomic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp57 |
| Official Name | zinc finger protein 57 [Source:MGI Symbol;Acc:MGI:99204] |
| Ensembl ID | ENSMUSG00000036036 |
| Bio databases IDs | |
| Aliases | zinc finger protein 57 |
| Synonyms | bA145L22, bA145L22.2, C6orf40, G19, LOC346171, TNDM1, ZFP57 zinc finger protein, zinc finger protein 57, ZNF698 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp57 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- krueppel associated box
- transcription regulator
- double-stranded DNA binding
- chromatin binding
- protein binding
- zinc finger domain
- KRAB (Kruppel-associated box) domain -A box
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- breast cancer
- epithelial cancer
- hepatocellular carcinoma
- heart failure
- esophageal cancer
- transient neonatal diabetes mellitus 1
- colorectal cancer
- gout
role in cell
- proliferation
- apoptosis
- expression in
- growth
- G1 phase
- migration
- morphology
- colony formation by
- demethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp57 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity