Prr5 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5 (proline rich 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prr5 |
| Official Name | proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] |
| Ensembl ID | ENSMUSG00000036106 |
| Bio databases IDs | |
| Aliases | proline rich 5 (renal) |
| Synonyms | Arhgap8, C030017C09Rik, FLJ20185k, PP610, proline rich 5, proline rich 5 (renal), PROTOR-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HbrB-like
- GTPase activator
- protein binding
Pathways
Biological processes and signaling networks where the Prr5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- squamous cell cancer
- epithelial cancer
- Barrett syndrome
- Huntington disease
- insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- monoclonal gammopathy of undertermined significance
- glioblastoma
- glioblastoma cancer
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- protein kinase B signaling cascade
- cellular response to nutrient levels
- cytoskeleton organization
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- TORC2 complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding