Tbc1d21 Gene Summary [Mouse]
Enables actin binding activity. Involved in sperm axoneme assembly and sperm mitochondrial sheath assembly. Located in acrosomal vesicle and sperm midpiece. Orthologous to human TBC1D21 (TBC1 domain family member 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d21 |
| Official Name | TBC1 domain family, member 21 [Source:MGI Symbol;Acc:MGI:1921536] |
| Ensembl ID | ENSMUSG00000036244 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 21 |
| Synonyms | 1700095K08Rik, MgcRabGAP, RGD1310243, TBC1 domain family member 21, TBC1 domain family, member 21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbc1d21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- actin binding
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm midpiece
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbc1d21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatogenesis
- sperm axoneme assembly
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- sperm midpiece
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- GTPase activator activity
- small GTPase binding