Vdac3 Gene Summary [Mouse]
Predicted to enable voltage-gated monoatomic anion channel activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in mitochondrion. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vdac3 |
| Official Name | voltage-dependent anion channel 3 [Source:MGI Symbol;Acc:MGI:106922] |
| Ensembl ID | ENSMUSG00000008892 |
| Bio databases IDs | |
| Aliases | voltage-dependent anion channel 3 |
| Synonyms | HD-VDAC3, voltage-dependent anion channel 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vdac3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic porin
- Eukaryotic porin family that forms channels in the mitochondrial outer membrane
- voltage-dependent ion-selective channel
- protein binding
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Vdac3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- asthenozoospermia
- growth failure
- sickle cell anemia
role in cell
- binding in
- growth
- motility
- abnormal morphology
- assembly
- morphology
- function
- long-term potentiation
- paired-pulse facilitation
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial outer membrane
- nuclear envelope
- sperm tail
- synaptic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vdac3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- spermatogenesis
- learning
- adenine transport
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- membrane
- pore complex
- synapse
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- voltage-gated anion channel activity
- porin activity
- protein binding