Arhgap26 Gene Summary [Mouse]
Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Is expressed in amygdala; diencephalon lateral wall mantle layer; hypothalamus mantle layer; olfactory epithelium; and telencephalon mantle layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Arhgap26 |
| Official Name | Rho GTPase activating protein 26 [Source:MGI Symbol;Acc:MGI:1918552] |
| Ensembl ID | ENSMUSG00000036452 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 26 |
| Synonyms | 1810044B20RIK, 2610010G17RIK, 4933432P15RIK, GRAF, GRAF1, GTPASE REGULATOR ASSOCIATED with FOCAL ADHESION KINASE PP125(FAK), mKIAA0621, OLIGOPHRENIN-1 LIKE, OPHN1L, OPHN1L1, Rho GTPase activating protein 26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phospholipid binding
- protein binding activity, bridging
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- Bin/Amphiphysin/Rvs domain
- phosphorylation site
- Src Homology 3 domain superfamily
- BAR domain of APPL family
- IRSp53/MIM homology domain
- PH domain
- BAR domain
Pathways
Biological processes and signaling networks where the Arhgap26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- acute lymphoblastic leukemia
- coronary artery disease
- juvenile myelomonocytic leukemia
- habitual abortion
- myocardial infarction
- septic shock
- early missed abortion
- small vessel disease stroke
regulates
- RAS homolog
- RHOA
role in cell
- differentiation
- fusion
- downregulation in
- endocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Mitochondria
- cytosol
- membrane ruffles
- endosomal membrane
- perinuclear space
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
- nervous system development
- macromitophagy
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- mitochondrion
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- phospholipid binding
- protein binding, bridging