PHPT1 Gene Summary [Human]
This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | PHPT1 |
| Official Name | phosphohistidine phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30033] |
| Ensembl ID | ENSG00000054148 |
| Bio databases IDs | |
| Aliases | phosphohistidine phosphatase 1, phosphohistidine phosphatase 14kDa, sex-regulated protein janus-a |
| Synonyms | 1700008C22Rik, CGI-202, HEL-S-132P, HSPC141, phosphohistidine phosphatase 1, PHP, PHP14, SRP JANUS-A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHPT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Janus/Ocnus family (Ocnus)
- calcium channel inhibitor
- protein phosphatase
- enzyme inhibitor activity
- phosphatase
- ion channel binding
- phosphorus-nitrogen bond hydrolase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHPT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-histidine dephosphorylation
- negative regulation of T cell receptor signaling pathway
- negative regulation of lyase activity
- protein dephosphorylation
- negative regulation of ATP citrate synthase activity
- actin cytoskeleton organization
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- nuclear body
- extracellular vesicular exosome
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- ion channel binding
- calcium channel inhibitor activity