Rad23b Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within DNA repair; cellular response to interleukin-7; and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; liver; and retina nuclear layer. Orthologous to human RAD23B (RAD23 homolog B, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad23b |
| Official Name | RAD23 homolog B, nucleotide excision repair protein [Source:MGI Symbol;Acc:MGI:105128] |
| Ensembl ID | ENSMUSG00000028426 |
| Bio databases IDs | |
| Aliases | RAD23 homolog B, nucleotide excision repair protein |
| Synonyms | 0610007D13Rik, HHR23B, HR23B, mHR23B, P58, RAD23 homolog B, nucleotide excision repair protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad23b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- XPC-binding domain
- nucleic acid binding
- transcription factor binding
- STI1 domain
- protein binding
- ubiquitin-like domain
- sequence-specific DNA binding
- Ubiquitin family
- UV excision repair protein Rad23
- single-stranded DNA binding
- double-stranded DNA binding
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- Ubiquitin-2 like Rad60 SUMO-like
Pathways
Biological processes and signaling networks where the Rad23b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- blepharitis
- edema
- eyelids open at birth
- cleft lip
- prostate cancer
- motor dysfunction or movement disorder
- conjunctivitis
- rectal prolapse
role in cell
- apoptosis
- activation in
- formation
- formation in
- binding in
- abnormal morphology
- pluripotency
- recognition
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad23b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- spermatogenesis
- nucleotide-excision repair
- embryonic organ development
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- XPC complex
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteasome binding
- ubiquitin binding
- polyubiquitin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- damaged DNA binding
- single-stranded DNA binding