Zcchc12 Gene Summary [Mouse]
Enables SUMO binding activity and transcription coactivator activity. Acts upstream of or within BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Located in PML body and nuclear speck. Is expressed in several structures, including central nervous system; gut; paravertebral ganglion; retina; and skeletal musculature. Orthologous to several human genes including ZCCHC12 (zinc finger CCHC-type containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zcchc12 |
| Official Name | zinc finger, CCHC domain containing 12 [Source:MGI Symbol;Acc:MGI:1919943] |
| Ensembl ID | ENSMUSG00000036699 |
| Bio databases IDs | |
| Aliases | zinc finger, CCHC domain containing 12 |
| Synonyms | 2810028A01Rik, PNMA7A, SIZN, SIZN1, zinc finger, CCHC domain containing 12, zinc finger CCHC-type containing 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zcchc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SUMO interaction motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- thyroid carcinoma
- epithelial thyroid cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
regulates
- AKT
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- PI3K (family)
role in cell
- proliferation
- phosphorylation in
- apoptosis
- migration
- S phase
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zcchc12 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding