Kpna3 Gene Summary [Mouse]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytosol. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kpna3 |
| Official Name | karyopherin (importin) alpha 3 [Source:MGI Symbol;Acc:MGI:1100863] |
| Ensembl ID | ENSMUSG00000021929 |
| Bio databases IDs | |
| Aliases | karyopherin (importin) alpha 3 |
| Synonyms | hSRP1, importin, Importin alpha 4, Importin α 4, IPOA4, Karyopherin alpha3, Karyopherin (importin) alpha 3, Karyopherin (importin) α 3, karyopherin subunit alpha 3, karyopherin subunit α 3, Karyopherin α 3, SPG88, SRP1, SRP1gamma, SRP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpna3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Atypical Arm repeat
- HEAT-like repeat
- importin beta binding domain
- Armadillo/beta-catenin-like repeats
- protein binding
- HEAT repeats
- nuclear localization sequence binding
- transporter
Pathways
Biological processes and signaling networks where the Kpna3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dysferlinopathy
- autosomal dominant spastic paraplegia type 88
- chronic obstructive pulmonary disease
- Parkinson disease
- psoriasis
- uterine leiomyoma
- leiomyomatosis
- NPM1 mutation positive acute myeloid leukemia
- chronic lymphocytic leukemia
role in cell
- processing in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpna3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- macromolecular complex assembly
- protein import into nucleus
- NLS-bearing substrate import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- NLS-dependent protein nuclear import complex
- host cell
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- nuclear localization sequence binding