Zcchc12 Gene Summary [Rat]
Predicted to enable SUMO binding activity and transcription coactivator activity. Predicted to act upstream of or within BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body and nuclear speck. Predicted to be active in nucleus. Orthologous to human ZCCHC12 (zinc finger CCHC-type containing 12) and ZCCHC18 (zinc finger CCHC-type containing 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zcchc12 |
| Official Name | zinc finger CCHC-type containing 12 [Source:RGD Symbol;Acc:1359439] |
| Ensembl ID | ENSRNOG00000013162 |
| Bio databases IDs | |
| Aliases | zinc finger CCHC-type containing 12 |
| Synonyms | 2810028A01Rik, PNMA7A, SIZN, SIZN1, zinc finger, CCHC domain containing 12, zinc finger CCHC-type containing 12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zcchc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SUMO interaction motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- thyroid carcinoma
- epithelial thyroid cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
regulates
- AKT
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- PI3K (family)
role in cell
- proliferation
- phosphorylation in
- apoptosis
- migration
- S phase
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zcchc12 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding